Postdoctoral Fellow in Neuroscience (Drosophila Neurobiology)

Website Case Western Reserve University

The Tabuchi Lab in the Department of Neurosciences at Case Western Reserve University seeks a highly motivated postdoctoral fellow to study how neural coding impacts signaling, plasticity, and behavior, using the fruit fly Drosophila as a model system. Applicants should have a PhD and/or MD degree and be energetic and creative.  Candidates with strong training in molecular genetics, biochemistry, functional imaging, electrophysiology, and/or computational analysis are desired. The lab applies multidisciplinary approaches in Drosophila to understand how non-canonical (temporal or analog) neural codes represent persistent internal states such as arousal and hunger. In addition, the lab seeks to identify novel pathological mechanisms of neurodegenerative diseases, such as Alzheimer’s disease. Our research scope includes hierarchical interactions of gene expression, biophysical properties such as ionic currents, temporal structure of membrane potential dynamics including spiking patterns, functional synaptic connectivity of neural circuits, and behavior.

For more information, please visit our website: http://tabuchilab.org/

Key Publications:

Tabuchi M#, Coates KE, Bautista OB, Zukowski LH. (2021). Light/Clock Influences Membrane Potential Dynamics to Regulate Sleep States Frontiers in Neurology 12:625369. #corresponding author.

Blum ID, Keles M, Baz ES, Han E, Park K, Luu S, Issa H, Brown M, Ho MCW, Tabuchi M, Liu S, Wu MN. (2021). Astroglial Calcium Signaling Encodes Sleep Need in Drosophila. Current Biology 31(1): 150-162.

Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE. (2020). TRPV4 Disrupts Mitochondrial Transport and Causes Axonal Degeneration via a CaMKII-dependent Elevation of Intracellular Ca2+. Nature Communications 11(1):2679.

Xie X, Tabuchi M, Corver A, Duan G, Wu MN, Kolodkin AL. (2019). Semaphorin-2b Regulates Sleep Circuit Formation in the Drosophila Central Brain. Neuron 104(2):322-337.

 Tabuchi M, Monaco JD, Duan G, Bell BJ, Liu S, Liu Q, Zhang K, Wu MN. (2018). Clock-Generated Temporal Codes Determine Synaptic Plasticity to Control Sleep. Cell 175(5): 1213-1227.

Xie X, Tabuchi M, Brown MP, Mitchell SP, Wu MN, Kolodkin AL. (2017). The Laminar Organization of the Drosophila Ellipsoid Body Is Semaphorin-Dependent and Prevents the Formation of Ectopic Synaptic Connections. eLife e25328.

Liu Q*, Tabuchi M* (co-first author), Liu S, Kodama L, Horiuchi W, Daniels J, Chiu L, Baldoni D, Wu MN. (2017). Branch-Specific Plasticity of a Bifunctional Dopamine Circuit Encodes Protein Hunger. Science 356, 534-539.

Tabuchi M, Lone SR, Liu S, Liu Q, Zhang J, Spira AP, Wu MN. (2015). Sleep Interacts with Aβ to Modulate Intrinsic Neuronal Excitability. Current Biology 25(6):702-712.

To apply: Please send Cover letter, CV and the names of three references to Dr. Masashi Tabuchi.

Masashi Tabuchi, Ph.D.

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Department of Neurosciences, Case Western Reserve University School of Medicine

10900 Euclid Avenue, Cleveland, Ohio 44106, USA

Email: masashi.tabuchi@case.edu

To apply for this job please visit case.edu.

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