SRBR: Society for Research on Biological Rhythms

Which intracellular events and in which cells regulate #sleep? Here @hiromasafunato identify a SIK3-HDAC4 pathway in excitatory neurons that regulate non REM sleep and wakefulness:

https://www.nature.com/articles/s41586-022-05450-1

An exciting set of findings from @ScheiermannLab show that cancer immunotherapy is more effective when synchronized with dendritic cell anti-tumor functions. Yet another example of how understanding cellular rhythms can be exploited therapeutically:

https://www.nature.com/articles/s41586-022-05605-0

Time-of-day differences in immune responses to vaccines exist but the mechanisms remain poorly understood. Here @curtisclocklab @mariankiskis show mitochondrial calcium rhythms, which regulate morphology and metabolism, are important:

https://www.nature.com/articles/s41467-022-34897-z

Like adults, children's circadian systems are highly sensitive to light, as @laurenhartstein et al show in their new #JBR paper. Can bright light before bed explain difficulty in getting children to sleep? Read more here:

https://doi.org/10.1177/07487304221134330