SRBR: Society for Research on Biological Rhythms

To understand the specific roles of CRY1 and CRY2 in the circadian clock, the Hirota and @drstevekay labs characterise the small molecule, SHP656 (and an isoform SHP1703), with structure and function analyses, to show it is specifically inhibits CRY2:

https://www.pnas.org/doi/10.1073/pnas.2203936119

Bioluminescent assays are a key method in #chronobiology; a challenge has always been using this in live organisms. Here, the Top lab develop a technique to measure the oscillation of distinct neuronal and peripheral clocks in live Drosophila #flyclock:

https://doi.org/10.7554/eLife.77029

The International Agency for Research on Cancer @iarcwho classifies shift work as “probably carcinogenic to humans” (Group 2A). Here, the @katialamia lab demonstrate a molecular mechanism for increased tumor burden under chronic jet lag - HSF1 signalling:

https://www.science.org/doi/10.1126/sciadv.abo1123#.YzSxMsp6I1E.twitter

From the (recent) past: Gene-based molecular clocks are proposed to generate an internal time of ~24h, but the genes involved aren't conserved across all branches of life. @ProfMBrunner propose CK1 and disordered proteins as a conserved timing module:

https://www.pnas.org/doi/10.1073/pnas.2118286119