Cincinnati Children's Research Foundation
A postdoctoral Research Fellow position is available immediately in Dr. Mattia Quattrocelli’s laboratory in the Division of Molecular Cardiovascular Biology in the Heart Institute. The Quattrocelli lab investigates the interplay between metabolic, circadian, and epigenetic mechanisms to govern pharmacology and physiology of cardiovascular disease and skeletal muscle disorders. We are expanding our research interest from basic mechanisms of striated muscle function to complex disease contexts like aging, diabetes, heart failure and muscle wasting. Moreover, we are interested in linking functional outcomes to the crosstalk between striated muscle cells and other cells or tissues of relevance, such as adipose tissue, liver, immune cells, etc. The studies in our lab routinely use multidisciplinary combinations of transgenic mice, omics datasets, metabolic assays, circadian modulation, in vitro/ex vivo isotope tracing, primary cell lines and human induced pluripotent stem cells. The laboratory is committed to support postdoctoral fellows in any career aspirations (academia, industry, etc.).
Recent publications from the lab:
1) Wintzinger et al, Impact of circadian time of dosing on cardiomyocyte-autonomous effects of glucocorticoids, Mol Metab. 2022.
2) Quattrocelli et al, Intermittent prednisone treatment in mice promotes exercise tolerance in obesity through adiponectin. J Exp Med. 2022.
3) Quattrocelli et al, Muscle mitochondrial remodeling by intermittent glucocorticoid drugs requires an intact circadian clock and muscle PGC1α. Sci Adv. 2022.
Requirements: A Ph.D. in a related discipline, M.D. or equivalent degree is required. Recent Ph.D. candidates with research experience in molecular/cellular biology, biochemistry and/or physiology are encouraged to apply. Experience with mouse physiology and/or primary/pluripotent cell culture is preferred but not required. The ideal candidate should work well in teams as well as independently, and be organized, self-motivated and hardworking.
Please submit your application to Dr. Quattrocelli with the following information: cover letter, CV, and contact details for 3 referees.
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For further information about working at CCHMC, please contact the Postdoc recruiter: Uma Sivaprasad, Ph.D. at firstname.lastname@example.org
Cincinnati Children’s Hospital Medical Center is an Affirmative Action/ Equal Opportunity Institution
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