SRBR Circadian Medicine Course

SRBR Circadian Medicine Course 

Course Fees:

  • Course Only – $250 (20% off for health providers practicing in Puerto Rico)
  • Course added to full registration: $50
    (Prices include the cost of CEs for physicians and nurses. Credits will be secured upon completion of an evaluation of the course, as required by Amedco.

Target audience: Physicians, nurses, pharmacists
Goal: To train medical professionals on the importance of circadian rhythms and clocks for their clinical practice.

Syllabus

[Morning: framework/background]

Introduction to circadian rhythms (with clinical/translational focus)

Relevant molecular/cellular biology
Concept of central and peripheral oscillators
Interactions of sleep and circadian rhythms for health
Implications for translating basic science to clinical practice 

  • Research on nocturnal animals while humans are diurnal 
  • Importance of documenting time of testing or intervention (clock time, circadian time, time since awakening) 
    • Nighttime “dipping” of BP as prognostic factor 
    • Phase dependence of characteristic changes 
    • Inter-personal and inter-daily differences that make “averages” less helpful  
    • Methods and pitfalls of analyzing these data 

Conceptual frameworks for circadian medicine

Etiology, health/disease balance/recovery 

Effect type: exposure, mediator, moderator, outcome

Detecting/ targeting/exploiting circadian clock  

Circadian influences on etiology of diseases/disorders

Metabolism, Cancer, Mental health, Neurodegenerative disorders, Learning and performance
Circadian examples: jet lag, social jet lag, position within a time zone 

Time-based diagnostics

Calculation of circadian parameters: 

  • Predictable power of single-time vs. 24-h based diagnostics Continuous monitoring 
  • Wearable devices, new technologies for continuous physiological assessment 
  • Data from hospitals 
  • Pitfalls of clinical data 

When important to know circadian “time” for clinical care (diagnosis, monitoring, treatment) 

Chronopharmacology

Chronopharmacodynamics and chronopharmacokinetics 

  • Examples of known drugs in which timing of administration affects efficacy and/or side effects 

Evidence-based approach

Omics-based approach 

[Afternoon: specifics]

Circadian rhythm sleep disorders

Genetics of CRSDs 
Delayed sleep-wake phase disorder
Advanced sleep-wake phase disorder
Irregular sleep-wake rhythm disorder 
Non-24-hour sleep-wake disorder 

The circadian medicine clinic

Questionnaires
Actimetry, heartrate, blood pressure, sleep sensors
Phase determination 

Circadian-healthy hospital beds and post-visit practices

Zeitgeber control: light, food, noise, drug administration 

Circadian-Based Cognitive Behavioral Therapy for Sleep Disorders

Manipulating zeitgebers: food, activity, light, temperature 

Implementing circadian-based practices

For pharmacists (in hospital and community pharmacy
For clinic-based nurses
For clinic-based physicians
For in-patient-based physicians